Data published in Frontiers in Immunology indicated that the combination of Limosilactobacillus fermentum SX-0718*, Lacticaseibacillus casei SX-1107*, Bifidobacterium longum SX-1326, and B. animalis SX-0582 also upregulated the expression of Sirt 1 to protect neurons in the hippocampal region of the brain.
Additionally, the probiotic combination, which was isolated from the feces of seven centenarians of the Centenarian Village in Ganzhou, Jiangxi province, China, was associated with an increase in the expression of molecules that improve the integrity of the intestinal barrier and reduce leaky gut.
“These changes underlie improved spatial memory, motor function and exploratory behavior of aging mice,” wrote scientists from the First Affiliated Hospital of Nanchang University and the Institute of Translational Medicine at Nanchang University.
“Our research provides the basis for the probiotic combination to become a dietary supplement for anti-aging.”
“Not bad for a probiotic-based intervention”
Commenting independently on the study, Mark Miller, PhD, Principal at Kaiviti Consulting, LLC, told NutraIngredients-USA: “This is a solid and insightful preclinical research study that takes the premise that the gut microbiome of centenarians possess elements that may drive anti-aging outcomes. Using the accelerated aging mouse model, SAMP-8, they demonstrated clear gut benefits but also an improvement in behavior aligned with a more youthful state.
“Mechanistically it appears that a cocktail of 4 probiotic species limited an aging-related gut dysbiosis, limited gut inflammation and improved the intestinal barrier function.