Plasmalogens alleviate age-related cognitive decline in mice – Anti Aging News

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This article was written by Arkadi Mazin at Lifespan.io who is an op-ed author with a passion for learning and exploration and is interested in the social aspects of longevity and life extension. He believes that life extension is an achievable and noble goal that has yet to take its rightful place on the very top of civilization’s agenda.

https://www.lifespan.io/news/plasmalogens-alleviate-age-related-cognitive-decline-in-mice/

https://pubmed.ncbi.nlm.nih.gov/35281262/

[1] Gu, J., Chen, L., Sun, R., Wang, J. L., Wang, J., Lin, Y., … & Fu, L. (2022). Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice. Frontiers in Molecular Biosciences, 159.

[2] Han, X., Holtzman, D. M., & McKeel Jr, D. W. (2001). Plasmalogen deficiency in early Alzheimer’s disease subjects and in animal models: molecular characterization using electrospray ionization mass spectrometry. Journal of neurochemistry, 77(4), 1168-1180.

[3] Fujino, T., Yamada, T., Asada, T., Tsuboi, Y., Wakana, C., Mawatari, S., & Kono, S. (2017). Efficacy and blood plasmalogen changes by oral administration of plasmalogen in patients with mild Alzheimer’s disease and mild cognitive impairment: a multicenter, randomized, double-blind, placebo-controlled trial. EBioMedicine, 17, 199-205.

[4] Dorninger, F., Forss‐Petter, S., & Berger, J. (2017). From peroxisomal disorders to common neurodegenerative diseases–the role of ether phospholipids in the nervous system. FEBS letters, 591(18), 2761-2788.

[5] Sartori, A. C., Vance, D. E., Slater, L. Z., & Crowe, M. (2012). The impact of inflammation on cognitive function in older adults: implications for health care practice and research. The Journal of Neuroscience Nursing, 44(4), 206.

[6] Babcock, K. R., Page, J. S., Fallon, J. R., & Webb, A. E. (2021). Adult hippocampal neurogenesis in aging and Alzheimer’s disease. Stem Cell Reports, 16(4), 681-693.

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