Barcelona [Spain], August 26 (ANI): A new study found that exposure to tobacco smoke in early childhood was associated with accelerated biological aging.
The results of this study were published in the journal “Environment International”.
Accelerated biological aging is associated with exposure to tobacco smoke during pregnancy and early childhood, and indoor exposure to black carbon.
These are the conclusions of an analysis led by the Barcelona Global Health Institute (ISGlobal), an organization backed by the La Caixa Foundation, which links numerous childhood environmental exposures to the epigenetic age of children. Is the first evaluation. ..
Exposure to environmental factors during pregnancy and early childhood can significantly (and in some cases irreversibly) alter metabolic and physiological functions, thereby determining health status in later years.
It may also accelerate the process of biological aging associated with an increased risk of metabolic, cardiovascular, or neurodegenerative disease.
At the cellular level, aging is a continuous process that begins early in life and can be measured thanks to an epigenetic clock. The epigenetic clock uses the level of DNA methylation in specific regions of the genome to infer human biological aging.
“Epigenetic watches make it possible to assess whether someone’s biological age is older or younger than his or her chronological age,” said IS Global’s researcher at the end of the study. The author, Mariona Bustamante, explained.
Some studies have shown an association between accelerated epigenetic aging and specific environmental exposures, but most are in adults and focus on a single exposure.
In this study, a team led by Bustamante used childhood exposomes (83 prenatal exposures, 103 early childhood exposures) and the epigenetic age of 1,173 children from early human ages 6 to 11 years. I investigated the relationship with for the first time. The Life Exposome (HELIX) project is based on six birth cohorts in six European countries, including Spain, and is coordinated by IS Global researcher Martine Vrijheid.
After selecting the best epigenetic clock for the study and adjusting for multiple factors, the research team found that exposure of pregnant mothers to tobacco smoke was associated with accelerated epigenetic aging. bottom.
For postnatal exposomes, the analysis showed an association between two exposures: indoor levels of black carbon, an air pollutant resulting from parental smoking and incomplete combustion of fuel (and particulate matter absorbance or PMabs). Indirectly measured by).
Interestingly, the other two variables were associated with delayed biological aging. Organic pesticide DMDTP and persistent organic pollutants (polychlorinated biphenyl-138).
“Further research is needed to explain these results, the former may be due to high fruit and vegetable intake and the latter may be explained by a correlation with body mass index. “, Studying.
“The positive link between accelerated epigenetic age and exposure to tobacco smoke during pregnancy and early childhood is consistent with previous results obtained in the adult population,” said Bustamante. rice field.
Epigenetic modifications affect inflammation, toxin removal, pathways involved in the cell cycle, and can subsequently affect health.
Indeed, these associations have not proven causal, but this and early future exposome studies are to reduce certain environmental exposures and promote “healthy aging” from early life stages. Helps guide your health policy. (ANI)