In a recent study funded by German biotech solutions firm MedSkin Solutions Dr. Suwelack, published in the Journal of Cosmetics, Dermatological Sciences and Applications, researchers say they have overcome the solubility, chemical instability and bioavailabilty challenges to develop an effective test product with 2% resveratrol concentration.
“This study demonstrates that a cosmetic product with resveratrol in the right bioactive form and the right concentration has significant anti-aging benefits and properties,” Ciska Janssens-Böcker, head of clinical affairs at MedSkin Solutions Dr. Suwelack told CosmeticsDesign-USA.
Effective in higher doses
Resveratrol, a polyphenol found in plant species such as grapes, peanuts and Japanese knotweed, is used in many nutraceutical formulations due to its potent antioxidant and anti-inflammatory properties.
In skin care products, it is increasingly added in low doses as an anti-aging ingredient, but the study recalls that resveratrol must be used at relatively high concentration to be effective in topical in vivo application. Previous studies have demonstrated that the biological activity of resveratrol depends on its concentration in soluble trans form.
“Our constant focus is on developing effective formulations that contain ingredients in their most active form and in the right concentration, so that the active ingredient penetrates the skin in its most active form,” Ciska Janssens-Böcker explained.
Researchers noted at the time of the study that they were unaware of other water-based creams with a concentration as high as 2% of solubilized, bioavailable trans-resveratrol on the market.